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They reduce hunger signals, slow stomach emptying, and support insulin secretion, which together result in reduced caloric intake and gradual, sustained weight loss

Many of these changes are regulated by pathways downstream of glutamine, for instance, DNA methylation can be reversed through the removal of oxidised methylated bases by TET proteins, which require KG (Ito et al, 2011)

The Bottom Line for Men GLP-1 medications dont directly replace testosterone therapy, and theyre not marketed as a hormonal treatment

Serious adverse events are uncommon but may include: Pancreatitis or gallbladder inflammation Allergic reactions Rare gastrointestinal disturbances Because of these potential risks, GLP-1 therapy should always be initiated and monitored by a doctor experienced in metabolic medicine

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Klein-Nulend et al., 2012)